Ivermectin is a medication used for treating certain types of skin lesions and parasitic infections. It works by interfering with a parasite’s nervous system to paralyze and ultimately kill it. Ivermectin is approved in the United States and Canada under the brand name Stromectol. Stromectol is indicated for the treatment of intestinal (i.e., non disseminated) strongyloidiasis due to the nematode parasite Strongyloides stercoralis and for the treatment of onchocerciasis due to the nematode parasite Onchocerca volvulus. With the advent of 2021 and the COVID-19 pandemic, ivermectin began garnering notoriety due to its off-label use for the prophylaxis and treatment of COVID-19.
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What Stromectol is used for
Ivermectin in a pill form is used to treat parasitic worms in humans. A topical form of the drug is used to treat head lice and skin conditions such as rosacea. Stromectol is an antiparasitic medicine used to treat the following infection:
- Treatment of intestinal strongyloidiasis.
- Treatment of parasites in the blood or tissue caused by Wuchereria bancrofti.
- Treatment of human scabies after prior treatment has failed.
- Treatment of rosacea. It should be noted that Stromectol is not effective in all cases of rosacea, because this disease can have various causes, including disruption of the endocrine system, infectious diseases, pathologies of the digestive tract, etc.
- Covid-19 (off-label). Ivermectin is a well-characterized drug that is used to treat parasitic infections in both humans and animals. Laboratory based studies have shown ivermectin can inhibit SARS-CoV-2 (the virus causing COVID-19) replication, raising the possibility that ivermectin may have a role in COVID-19 prophylaxis or treatment.
In veterinary medicine, it is used to prevent and treat heartworm and acariasis, among other indications.
Ivermectin is an effective medication against various parasites because at low concentrations it binds strongly to important components of nerves and muscles that worms have but that we, as vertebrates, don’t have.
Strongyloidiasis is an infection caused by the roundworm Strongyloides stercoralis. This tiny worm is barely visible to the naked eye. Exposure occurs when skin has direct contact with contaminated soil. Young roundworms penetrate the skin. They migrate through the bloodstream to the lungs and up the large airways. The worms are then swallowed, and the young worms mature and bury themselves into the intestinal wall. Adult roundworms begin producing eggs in the intestines.
This is a parasite that is carried and transmitted by the mosquito. It travels through the bloodstream and settles in the lymph and tissue of the patient, this can lead to fever and severe inflammation around the area the parasite has migrated to.
Scabies is an infectious disease of the skin caused by a mite barely visible to the human eye called Sarcoptes scabiei var hominis. The mite burrows into the skin and causes a rash like reaction which can be very itchy and uncomfortable for the patient. Human scabies is almost always caught from another person by close contact.
Ivermectin for preventing and treating COVID-19
Throughout the pandemic, the anti-parasite drug ivermectin has attracted much attention, particularly in Latin America, as a potential way to treat COVID-19. Novel coronavirus, causes infection that, while mild to moderate in many people, can lead to severe disease in a significant portion. Currently, it is expected that the majority, 81%, of patients with COVID-19 will have mild to moderate disease, with 14% having more severe disease (2). There exists a number of candidate drugs that may inhibit SARS-CoV-2 infection or progression of disease. Simple, safe and low-cost strategies that may be the best solution to inhibit infection and limit transmission and spread of infection.
Ivermectin is a drug initially synthesized and used as an anthelmintic. It has been found to have activity against several RNA viruses such as the SARS-CoV-2 by mechanisms that inhibit importin α/β-mediated nuclear transport that may prevent viral proteins from entering the nucleus to alter host cell function. A recent in vitro study showed that a single dose of ivermectin could kill COVID-19 in vitro within 48 hours. A recent multi-continent retrospective study of 1,400 patients demonstrated an association of ivermectin use with lower in-hospital mortality 1.4% versus 8.5%. Given these findings and its safety profile, cost and ease of administration, Ivermectin warrants study as a potential treatment to prevent progression of COVID-19 infection.
Mechanism of action
Ivermectin binds selectively and with high affinity to glutamate-gated chloride ion channels in invertebrate muscle and nerve cells of the microfilaria. This binding causes an increase in the permeability of the cell membrane to chloride ions and results in hyperpolarization of the cell, leading to paralysis and death of the parasite. Ivermectin also is believed to act as an agonist of the neurotransmitter gamma-aminobutyric acid (GABA), thereby disrupting GABA-mediated central nervous system (CNS) neurosynaptic transmission. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite.
When was Ivermectin approved for humans?
Ivermectin was discovered in 1975 and is approved for use in humans to treat infections caused by some parasitic worms, head lice and skin conditions such as rosacea. When taken in appropriate, prescribed doses it can be highly effective and is included in the World Health Organization’s list of essential medicines.
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Ivermectin and COVID-19
As was seen with the interest in hydroxychloroquine use in the early stages of the COVID-19 pandemic, there are many ongoing clinical studies (of varying quality) to assess the effectiveness of ivermectin as a treatment for COVID-19.
Ivermectin was one of many drugs medical professionals reviewed for repurposing early on in the COVID-19 pandemic. Some doctors gave the anti-parasitic drug to infected patients and saw seemingly positive effects. However, more studies show it has little to no effect when it comes to treating COVID-19. The drug has stayed in the headlines following podcaster Joe Rogan saying he used it after he tested positive for COVID.
Can ivermectin be used to treat COVID-19?
This is where things get complicated. Public health agencies, including the Federal Drug Administration, the National Institutes of Health and the World Health Organization, don’t suggest ivermectin’s use to treat COVID-19. They cite the lack of data from large, randomized trials confirming the drug’s effectiveness to treat the disease.
Some doctors who cite multiple smaller studies and firsthand experience say otherwise. They claim ivermectin does work to prevent people from developing symptoms from COVID-19 and can shorten recovery time for those already infected.
How to Get Ivermectin
To assist all who are having difficulty finding pharmacists to fill prescriptions for ivermectin for preventing or treating COVID-19, we offer a safe pharmacy that offers generic Stromectol with fast delivery.
Important Tips When Selecting an online pharmacy:
- Check online reviews.
- Ask about pricing for drugs.
- Ask where your order is being shipped from.
- If possible, check out more than one online pharmacy and compare costs.
- Check the US Food & Drug Administration pharmacy inspection reports and related records
How much does ivermectin pills cost?
Ivermectin is a macrocyclic lactone medicine used to treat parasitic infections. In Canada and the United States, ivermectin is available in 3 mg, 6 mg, 12 mg tablets (Stromectol™). Ivermectin cream (Soolantra™) was approved by the FDA in December 2014 but is not yet available for sale.
The cost for ivermectin oral tablet 3 mg is around $42 for a supply of 10 tablets, depending on the pharmacy you visit.
Ivermectin 3 mg
Dosage: 3 mg
Quantity: 10 tablets
Ivermectin 12 mg
Dosage: 12 mg
Quantity: 10 tablets
How much does a 3-mg dose of ivermectin cost compared with a 12-mg dose of the drug?
Your doctor will determine your dosage of ivermectin tablets based on your body weight. A doctor may prescribe a 12-milligram (mg) dose of ivermectin to treat a body lice or scabies infection. The cost of a lower dose may be slightly lower than the cost of a higher dose of the drug.
- The cost for ivermectin oral tablet 3 mg is around $42 for a supply of 10 tablets
- The cost for ivermectin oral tablet 12 mg is around $68 for a supply of 10 tablets
How to use
Take this medication by mouth with a full glass of water (8 ounces or 240 milliliters) on an empty stomach at least 1 hour before a meal. Ivermectin is usually taken as a single dose or series of doses, or as directed by your doctor.
Dosage is based on your weight, medical condition, and response to treatment.
Tell your doctor if your condition persists or worsens.
The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine.
The amount of medicine that you take depends on the strength of the medicine (3 mg, 6 mg, 12 mg). Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
For oral dosage form (tablets)
For river blindness:
Adults and teenagers — Dose is based on body weight and must be determined by your doctor. The usual dose is 150 micrograms (mcg) per kilogram (kg) (68 mcg per pound) of body weight as a single dose. The treatment may be repeated every three to twelve months.
Adults and teenagers — Dose is based on body weight and must be determined by your doctor. The usual dose is 200 micrograms (mcg) per kilogram (kg) (91 mcg per pound) of body weight as a single dose. Additional doses usually are not needed.
Adults and teenagers — Dose is based on body weight and must be determined by your doctor. If used for classic scabies, two doses of oral ivermectin (200µg/kg/dose) should be taken with food, each approximately one week apart. The safety of ivermectin in children weighing less than 15 kg and in pregnant women has not been established.
What happens if I miss a dose?
Since ivermectin is usually given in a single dose, you may not be on a dosing schedule. If you are on a schedule, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Can I Buy Ivermectin Online?
Many people wonder how to get ivermectin and if ivermectin over the counter (OTC) is available. All forms of ivermectin for humans, including ivermectin tablets and ivermectin cream, are prescription medications in the United States. Using Canada’s online medication delivery services, you can purchase Ivermectin tablets without a prescription and save up to 60%.
Why do Americans find the best prices for Ivermectin in Canada?
Americans spend nearly twice as much for Ivermectin tablets compared to what residents of other countries pay. The question becomes why are drugs so expensive in America and what can Americans do for better prices on Rx medications?
There is a monopoly pricing model that is unique to the pharma care industry in the USA. It leads to medications that are still branded (generics become available when patents on medications expire) having prices that the manufacturer sets at whatever level they like. There is less market regulation for pharmaceuticals in the USA, and that’s the primary reason why you’ll find better prices on drugs ordered from Canada.
Canada is the USA’s neighbour and a country where Ivermectin tablets typically cost less for people. As Americans can order drugs from Canadian pharmacies like Canadian Genius Meds, it is something to consider for anyone who wants to pay less for Ivermectin. Pay less when you order Ivermectin online from Canada.
Before taking ivermectin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems.
If you have traveled or lived in West or Central Africa, you may be infected with certain parasites (such as Loa loa, African trypanosomiasis) that could cause problems with ivermectin treatment. These effects could rarely result in serious (possibly fatal) effects on the brain (such as encephalopathy).
Asthma. Patients with a history of severe asthma should receive ivermectin with caution. Occasionally, systemic ivermectin has been reported to worsen bronchial asthma.
This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
If you have a weakened immune system (such as due to HIV infection), you may need repeat treatments with this medicine.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
Ivermectin passes into breast milk. Though there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.
To help your doctor or pharmacist give you the best care, be sure to tell your doctor or pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product.
Some of the products that may interact with this drug include: barbiturates (such as phenobarbital, butalbital), benzodiazepines (such as clonazepam, lorazepam), sodium oxybate (GHB), valproic acid.
This document does not contain all possible interactions. Keep a list of all the products you use. Share this list with your doctor and pharmacist to lessen your risk for serious medication problems.
What are the possible side effects of ivermectin?
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
- eye pain or redness, puffy eyes, problems with your vision;
- severe skin rash, itching, or rash with pus;
- confusion, change in your mental status, balance problems, trouble walking;
- fever, swollen glands, stomach pain, joint pain, swelling in your hands or feet;
- fast heart rate, trouble breathing;
- loss of bladder or bowel control;
- neck or back pain, seizure (convulsions); or
- a light-headed feeling, like you might pass out.
Common side effects may include:
- headache, muscle aches;
- nausea, diarrhea; or
- mild skin rash.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
STROMECTOL contains ivermectin 3 mg, 6 mg or 12 mg per tablet.
- microcrystalline cellulose
- pregelatinised maize starch
- magnesium stearate
- butylated hydroxyanisole
- citric acid
STROMECTOL does not contain lactose, sucrose, gluten, tartrazine or any other azo dyes.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature below 30 degrees C (86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.
This is a summary of information about this product. It is not medical advice. Ask your health care professional for complete information about this product and your individual health needs.